Table 1.

Comparison of the Performance of PEB and ST Rules at Various Positivity Thresholds by Using Blood Samples Collected From 701 Control Participants

Screening-Rule Threshold		Actual Specificity (%)	Total No. of FP Screens	No. of Unique Women Experiencing an FP Screen
ST CA125 (U/mL)	PEB z Score			ST	PEB
35	2.8	99.1	35	21	29
30	2.23	98.2	68	38	59
25	1.69	95.8	161	64	134
20	1.25	90.4	368	135	287

Abbreviations: FP, false-positive screen; PEB, parametric empirical Bayes; ST, single threshold.