Table 2.

Comparison of the Performance of the PEB and ST Rules at Various Positivity Thresholds by Using Blood Samples Collected From Case Participants (n = 44)

Screening-Rule Threshold		Actual Specificity (%)	No. of Cases Detected by Either the PEB or ST Rule That Were Detected Earlier, Later, or at the Same Screen by the PEB Rule Compared With the ST Rule			Difference in Years Between PEB- and ST-Positive Screens or Clinical Diagnosis Among Discordant Cases*				Average CA125 Value at Time of First Positive-PEB Screen
ST CA125 (U/mL)	PEB z Score		Earlier	Same	Later	Mean	Median	Max	Min
35	2.8	99.1	9†	23	0	0.9	0.93	1.29	0.12	20.1
30	2.23	98.2	12†	23	0	0.93	0.93	2.1	0.12	18.9
25	1.69	95.8	16†	19	0	1.06	1.09	2.1	0.12	17.4
20	1.25	90.4	15†	22	1	1.59	1.31	3.42	−0.08‡	16

Abbreviations: Max, maximum; Min, minimum; PEB, parametric empirical Bayes; ST, single threshold.

^*Discordant case was defined as a case identified earlier in time or missed by one of the decision rules.

^†All tests were significant(McNemar test). P values from top to bottom were < .008, < .001, < .001, and < .002, respectively

^‡Negative value reflects a case when the ST rule turned positive before to PEB.