Table 2.
Individual and trial-level correlation coefficients and sensitivity data for DFS and PFS
| Number of patients (trials) |
DFS or PFS vs overall survival |
3-year DFS or 2-year PFS vs 5-year overall survival (R2 [95% CI]) | ||
|---|---|---|---|---|
| Individual level (ρ2 [95% CI]) | Trial level (R2 [95% CI]) | |||
| Adjuvant therapy | ||||
| Chemotherapy vs no chemotherapy | 5379 (17) | 0·83 (0·83–0·83) | 0·92 (0·88–0·95) | 0·88 (0·83–0·93) |
| Radiotherapy+chemotherapy vs radiotherapy alone | 2247 (7) | 0·87 (0·87–0·87) | 0·99 (0·98–1·00) | 0·96 (0·93–0·99) |
| Locally advanced disease | ||||
| Radiotherapy+sequential chemotherapy vs radiotherapy alone | 1458 (8) | 0·77 (0·77–0·77) | 0·96 (0·93–0·99) | 0·77 (0·63–0·91) |
| Radiotherapy+concurrent chemotherapy vs radiotherapy alone | 2552 (15) | 0·85 (0·85–0·85) | 0·97 (0·96–0·99) | 0·95 (0·92–0·97) |
| Radiotherapy+sequential chemotherapy vs radiotherapy+concurrent chemotherapy | 1201 (6) | 0·83 (0·83–0·83) | 0·89 (0·81–0·97) | 0·75 (0·58–0·92) |
| Modified radiotherapy vs standard radiotherapy | 2685 (12) | 0·81 (0·81–0·81) | 0·96 (0·93–0·98) | 0·85 (0·78–0·93) |
DFS=disease-free survival. PFS=progression-free survival.