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Phenotypes of mouse MDSCs. Analysis of splenocytes from mice bearing 4T1 breast tumors evidence increased numbers of largish cells positive for CD11b (MAC1) and Gr1 (A). Gr1high MDSCs (green) are notable for Ly6G positivity (B) and the morphology of immature neutrophils (C). Gr1int MDSCs (blue) are notable for Ly6C positivity and partial F4/80 positivity (D) as well as monocyte/macrophage morphology, including pre-lineage forms.
