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. Author manuscript; available in PMC: 2013 Aug 2.
Published in final edited form as: Eur J Immunol. 2007 Mar;37(3):675–685. doi: 10.1002/eji.200636639

Figure 5.

Figure 5

IFN-γ-mediated neu antigen loss and tumor relapse in vivo. (A) Establishment of MMCr+ and MMCr− clones with the presence or lack of IFN-γ receptor alpha chain obtained from freshly isolated spontaneous mammary tumors or after a number of passages of MMC in vitro, respectively. (B) FVB mice (n=3) were depleted of CD4+ T cells and inoculated with MMCr+ or MMCr−. Tumor growth was monitored until 3 months after the challenge. RT-PCR analysis of neu mRNA expression in the tumors obtained from MMCr+-bearing FVB mice either at the plateau phase of tumor growth (day 40 post-challenge) or at the exponential growth phase (day 85 post-challenge).