Table 1.
Location and Amino Acid Sequence of the Three Phosphodegrons in the AAV2 Capsida
| Phosphodegron | Amino acid position (NCBI numbering) | Amino acid sequence (N-C terminus) | Average solvent accessibility (%) |
|---|---|---|---|
| 1 | 525–564 | ShKddeekffpqSgvlifgKqgsektnvdiekvmitdeee | 23.6 |
| 2 | 652–665 | pvpanpstTfSaaK | 35.0 |
| 3 | 489–507 | SKtsadnnnSeyswTgatK | 24.5 |
a
The predicted phosphorylation and ubiquitination sites (shown in boldface) that are highly conserved among all the serotypes of AAV within the phosphodegron region (shown enlarged) are listed. All three phosphodegrons are solvent accessible as shown by their high average solvent accessibility.