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Schematic representation of the serine (S), threonine (T), and lysine (K) residues mutated in adeno-associated virus serotype 8 (AAV8) and their conservation status across other AAV serotypes. VP1 protein sequences from AAV serotypes 1 through 10 were aligned by ClustalW, and the conservation status of each of the target sites for mutagenesis is shown in red. Color images available online at www.liebertpub.com/hgtb
