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K137R-AAV8 vector demonstrates superior hF.IX expression in comparison to WT-AAV8 vectors in C57BL/6 mice. Increased h.FIX expression from transgene constructs driven by either hAAT (A) or LP1 (B) promoters from animals injected with K137R-AAV8 vector and compared to the WT-AAV8 vector up to 8 weeks after hepatic gene transfer. *p<0.05 vs. WT-AAV8 injected mice.
