FIG. 6.

K137R-AAV8 vector elicits reduced inflammatory cytokine response compared to WT-AAV8 vectors in vivo. Quantitative PCR was used to profile the hepatic expression of key proinflammatory cytokines and other markers of innate immune response as described in the Materials and Methods section. The relative fold change in the target gene expression from mice injected with WT-AAV8 and K137R-AAV8 vector in comparison to mock-injected animals are shown. *p<0.05 denotes statistical significance as compared to the WT-AAV8-injected mice.