Table 2.
Physical Particle Packaging Titers (Viral Genomes/ml) of Various Serine/Threonine/Lysine Mutant AAV8 Vectors
Serine (S)>alanine (A) | Threonine (T)>alanine (A) | Lysine (K)>arginine (R) |
---|---|---|
S279A (8×1012) | T252A (8×1011) | K137R (4×1013) |
S501A (4×1013) | ||
S671A (4×1013) |
Average packaging titers from at least two packaging experiments are shown. The titer of wild-type self-complementary AAV8 vectors was 4×1013 viral genomes/ml in the laboratory.