Table 4.

Vector Biodistribution in Various Organs in C57BL/6 Mice 2 or 4 Weeks Post–Gene Transfer with the WT-AAV8 and S/T/K Mutant AAV8 Vectors

Vector type	Muscle	Liver	Kidney	Lung	Spleen	Heart
WT-AAV8 (4 weeks)	0.45±0.2	7.77±0.8	0.0016±0.00045	0.03±0.07	0.004±0.0009	0.0003±0.00006
K137R-AAV8 (4 weeks)	1.38±0.4	106.8±11	0.0011±0.0003	0.13±0.09	0.004±0.0006	0.0006±0.00004
S279A-AAV8 (4 weeks)	2.84±0.5	30.3±3.2	0.0029±0.0007	0.01±0.003	0.002±0.0005	0.0007±0.00001
S501A-AAV8 (4 weeks)	3.07±0.6	15±1.9	0.003±0.0008	0.11±0.08	0.0009±0.0008	0.003±0.0002
S671A-AAV8 (4 weeks)	1.89±0.3	65.89±5.6	0.0006±0.00012	0.051±0.01	0.001±0.0006	0.001±0.0008
WT-AAV8 (2 weeks)	0.008±0.08	0.51±0.1	0.0006±0.0002	0.0008±0.0002	0.022±0.009	0.0001±0.00005
T252A (2 weeks)	0.01±0.005	0.01±0.002	0.0001±0.00006	0.01±0.004	0.0005±0.00009	0.0006±0.00009

Values are shown as mean (±SD) vector copy numbers per mouse diploid genome.