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Effect of pasireotide (SOM230) on serum insulin (A) and glucose levels (B) in Pdx1-Cre:Men1 floxed/floxed conditional knockout mice with monthly subcutaneous injections of SOM230 (160mg/Kg/month [64mg/ml]) or PBS for four months.
*One-way repeated ANOVA was performed on data as long as there were at least 3 mice in each group (i.e., up to and including day 70)
†Indicates the occurrence of death (days 68, 74, and 82)
