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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Anesthesiology. 2013 Jul;119(1):142–155. doi: 10.1097/ALN.0b013e31828fc7e7

Figure 2.

Figure 2

Mechanical withdrawal thresholds of postnatal day (P)7 rat pups prior to (baseline) and at intervals (15, 30, 45, 60mins and 24hrs) following intrathecal injection of saline or 0.5mcl/g of 0.5% levobupivacaine. Graphs represent the log10 stimulus-response relationship between number of hindlimb withdrawal responses (0-5) and mechanical stimulus (grams, g) applied with graded von Frey hairs. Thresholds were higher in the levobupivacaine versus saline group at 15 minutes (log EC50 14.9g 95%CI: 11.8-18.0 versus 2.4g; 95%CI 2.0-2.9) and to a lesser degree at 30 minutes (log EC50 5.1g 95%CI: 4.3-6.0 versus 2.5g; 95%CI 2.1-3.0) . Data points = pooled mean ± SEM for saline (n=9) and levobupivacaine (n=9) groups.