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Differences in interactions (>50%) observed in Phe56Leu U1A-RNA complex simulation compared to wild type
| Residues | Positions | Type of interaction | Difference |
|---|---|---|---|
| Tyr13 – Leu56 | β1 to β3 | VDW | − 77% |
| Leu56 – C5 | β3 to RNA loop | VDW | − 72% |
| Ser48 – C10 | loop 3 to RNA loop | VDW | + 61% |
| U8 – C9 | RNA loop | H-bond (O2* of U8 – O4* of C9) | + 54 % |
| U8 – C9 | RNA loop | H-bond (O2* of U8 – O5* of C9) | + 55% |
| Lys22 – A-4 | loop 1 to RNA stem | VDW | − 50 % |
