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. 2013 Aug 2;8(8):e70252. doi: 10.1371/journal.pone.0070252

Table 3. Summary of clinical outcome studies in acute adult psychiatric settings.

Paper Country Design and Data Collection Total number of Participants N (male), diagnosis NEx NCt Mean Age (yrs) Outcomes Measures Summary of intervention: Experimental (E) Summary of intervention: Control (C) N sessions (S), frequencyduration Drop-outs Bias risk QS%
Cassity, 197637 USA Controlled study Pre-MT, Post-MT (2 wks) 12 (0) 6 6 E: 25 C :27 Group cohesion Peer acceptance IP relations SQ Guitar tuition with performance plus 6 hours daily community treatment program 6 hours daily community treatment program S  =  10 Daily over 2wks 2 M 41
8 Schizophrenia 4 4
1 Hyperchondrial neurosis 1 0
1 Depressive neurosis 1 0
1 Passive Dependent 0 1
1 Hysterical neurosis 0 1
Moe et al., 200073 NL Pre- Post Pre-MT, Post-MT (6 mths) 9(7) 9 29 Global functioning GAF Modified Guided Imagery in Music N/A S = 23-32 1pw over 6 months. 0 M 59
5 Schizotypal 5
3 Schizophrenia 3
1 Schizoaffective 1
Morgan et al., 201174 Australia RCT Pre-MT, Post-MT (2wks), f/u (1 mth) 60* (49 (23) Completed) *Analysis only on completed E: 35 C: 37 Anxiety, depression, stress Patient ward behaviour Depression Psychiatric symptoms DASS-21 NOSIE-30 Calgary BPRS Individual music therapy using improvisation or songwriting. Sitting with therapist listening to a pre-recorded CD playing relaxing nature sounds. S = 4 2pw over 2 weeks. 11 E:5 C:6 L 85
25 Schizophrenia 11 14
12 Schizoaffective 6 6
12 Bipolar 8 4
Odell-Miller et al., 200684 UK RCT Pre-MT, Mid (3 mths), Post-MT (6mths) PQRST: Monthly. 45 (10) Individual MT =  2 Group MT =  1 nr nr 37 Anxiety and depression Issues of importance to patient Clinical Outcomes Life skills HADS PQRST CORE LSP Arts therapies- Individual AT Group AT Individual DMT Individual MT* Group MT* Plus standard psychiatric support. *MT: improvisation Standard psychiatric support. Frequency NR 6 months 20 E:14 C:6 M 59
9 Schizophrenia nr nr
6 Bipolar nr nr
3 Depression nr nr
3 Residual depression nr nr
2 Schizoaffective nr nr
1 Dementia nr nr
1 Eating Disorder nr nr
Silverman & Marcionetti, 200496 USA Pre- Post Pre-MT, Post-MT (single session) 189 Gender: nr nr Self-reported Mood; Psychiatric symptoms; Feelings re: hospital; Self-esteem; Self-expression; Knowledge of coping skills; Managing anger; Appraisal of MT Researcher designed 10pt VAS 5 single interventions: 1. Group drumming 2. Music games 3. Lyric analysis 4. Songwriting 5. Music listening N/A S = 1 Single session 2pw over 3 weeks. Each offered 8 times. 0 M 37
Group drumming 48
Music Games 37
Lyric Analysis 34
Songwriting 35
Music Listening 35
Schizophrenia nr
Schizoaffective nr
Bipolar nr
Major Depressive Disorder nr
Psychosis nr
Silverman, 2009a100 USA RCT Post-MT (single session) 105 Gender: nr E: 37 C: 41 Social Functioning Patient appraisal Satisfaction with life Psycho- educational knowledge Therapist and patient verbalising in group Researcher designed scales: 1 =  worse 7 = better Helpful Enjoyment Comfort SWLS KIRI Observer rated Opening song; Lyric analysis focusing on relapse prevention and management of mental illness Scripted verbal psychoeducation with opening activity S = 1 Single session 2pw over 5 months. 28 of 32 sessions attended. E  = 15 sessions C = 13 sessions App: 1 SWLS 1 L 70
Bipolar nr
Major Depressive Disorder nr
Substance abuse nr
Schizoaffective nr
Schizophrenia nr
Silverman, 2011a102 USA 2 x RCTs Study 1: Pre-MT, 1 month f/u Study 2: Pre-MT, Post-MT (single session) Study 1: 30 Study 2: 29 Gender: nr nr Knowledge of coping skills PCI Songwriting, lyric analysis and music games to address psychoeducational objectives such as coping skills, relapse prevention, leisure skills, mental health knowledge. Psychoeducation objectives such as coping skills, relapse prevention, leisure skills, mental health knowledge without music. Study 1: S = 3 30mins, 3pw over 4 weeks. Study 2: S = 1 45mins single session. Study 1:21 E:11 C:10 Study 2: 0 M 63
Bipolar nr
Major depressive disorder nr
Schizoaffective nr
Substance abuse nr
Schizophrenia nr
Silverman, 2011b103 USA RCT Post-MT (single session) 89 (32) Mixed diagnoses: nr E: 37 C: 40 Coping skills Enjoyment Therapist and Patient Working alliance COPE Researcher designed scale 1 = Low 7 = High. HAQ-II Opening song to state name and how feeling; Songwriting concerning coping skills using 12-bar blues. Non-music psychoeducation group focused on coping skills. S = 1 Single session 1pw over 4 months. HAQ: 19 M 63
Talwar et al., 2006116 UK RCT Pre-MT, Post-MT (3 mths) 81 (60) Schizophrenia 33 48 E:35 C:39 Positive and negative symptoms Global Functioning Patient satisfaction PANSS GAF CSQ Individual music therapy using improvisation and talking to guide, interpret or enhance musical experience plus routine standard care. Routine standard care including nursing care and access to occupational, social and other inpatient activities. S = 12 1pw over 12 weeks. 12 E:5 C:7 L 89
Ulrich et al., 2007118 Germany RCT Pre-MT, post-MT 37 (20) 16 11 E:36 C:40 Negative symptoms IP contact: Nurse & Patient rated Quality of life SANS GT subscales 1, 5 and 6 SPG Structured group sessions using mainly active music making on rhythm instruments; structured improvisation, playing/singing pre-composed music, verbal reflection plus standard treatment. Standard treatment. S = 7-8 1-2 pw over 8 months. Average n sessions received  = 7.5 (sd 3.5) SANS: E:5 C:5 GTN: E:0 C:3 GT-P: E:4 C:3 SPG: E:4 C:2 L 82
27 Schizophrenia 16 11
4 Schizoaffective 3 1
1 Schizotypal 0 1
3 Drug induced psychosis 2 1
2 Depression with psychosis 0 2

BPRS- Brief Psychiatric Rating Scale, Calgary- Calgary Interview Guide for Depression, COPE- Brief COPE Inventory, CORE- Clinical Outcomes in Routine Evaluation, CSQ- Client Satisfaction Questionnaire, DASS-21- Depression, Anxiety and Stress Scale, GAF- Global Assessment of Functioning Scale, GT- Gießentest , HADS- Hospital Anxiety and Depression Scale, HAQ-II- Helping Alliance Questionnaire, KIRI- Knowledge of Illness and Resources Inventory, LSP- Life Skills Profile, NOSIE-30- Nurses’ Observation Scale for Inpatient Evaluation, PANSS- Positive and Negative Symptoms Scale, PCI- Proactive Coping Inventory, PQRST- Personal Questionnaire Rapid Scaling Technique, SANS- Scale for the Assessment of Negative Symptoms, SPG- Scales for Mental Health, SWLS- Satisfaction with Life Scale, SQ- Sociometric Questionnaire, VAS- Visual Analogue Scale

AT- Art Therapy, DMT- Dance Movement Therapy, MT, Music Therapy, nr- Not reported, N/A- Not applicable, pw- per week, IP relationship- Interpersonal Relationships