Table 3. The top epistasis interaction results from the 101 two-locus interaction analysis.
| Snp 1 | Genes | chr | Snp 2 | Genes | chr | N | P02 | P12 | PM2 |
| rs2187668 | HLADQ | 6 | rs4899272 | ACTN1 | 14 | 95 | 4.0E-17 | 1.42E-13 | 4.E-02 |
| rs204034 | SHISA9 | 16 | 94 | 1.3E-14 | 1.09E-12 | 5.E-02 | |||
| rs571879 | APPL1 HESX1 IL17RD. DNHD2. ASB14 | 3 | 94 | 2.3E-15 | 5.21E-11 | 3.E-02 | |||
| rs204999 | HLA | 6 | rs1073933 | COX7C | 5 | 94 | 9.9E-14 | 9.27E-12 | 3.E-02 |
| rs11836636 | ATXN7L3B KCNC2 | 12 | 91 | 1.1E-12 | 8.15E-11 | 4.E-02 | |||
| rs7745052 | FBXL4. C6orf168. USP45. COQ3. POU3F2. SFRS18 | 6 | 92 | 2.3E-05 | 1.79E-05 | 4.E-02 | |||
| rs10749738 | FOXD3 | 1 | rs1373649 | BMPR1B | 4 | 93 | 2.7E-05 | 1.78E-05 | 4.E-02 |
| rs3860295 | RASSF5 IKBKE | 1 | rs13096142 | CCR5 CCR3 LTF CCR2 CCR1 | 3 | 95 | 1.1E-05 | 6.48E-06 | 1.E-02 |
| rs9396802 | KIF13A NUP153 FAM8A1 | 6 | rs2194633 | NETO1 | 18 | 95 | 3.8E-06 | 6.82E-06 | 2.E-02 |
| rs9296204 | MTCH1 PI16 | 6 | rs4385459 | LY96 JPH1 GDAP1 TMEM70 TCEB1 | 8 | 95 | 2.8E-05 | 9.91E-06 | 3.E-02 |
| rs9397928 | ARID1B* | 6 | rs2415836 | FSCB* | 14 | 93 | 2.8E-05 | 1.75E-05 | 3.E-03 |
| rs1145212 | APOA5 ZNF259 BUD13 | 11 | rs10083673 | MYO5A | 15 | 95 | 6.6E-05 | 1.77E-05 | 2.E-03 |
| rs7756191 | DNAH8 | 6 | rs1108001 | NAV2 HTATIP2 DBX1 PRMT3 | 11 | 95 | 3.5E-05 | 2.60E-05 | 3.E-03 |
| rs10197319 | ICOS CTLA4 | 2 | rs882820 | SRL TFAP4 | 16 | 94 | 1.4E-05 | 3.03E-05 | 3.E-05 |
| rs4899272 | ACTN1 | 14 | rs17703807 | C15orf41 | 15 | 83 | 2.9E-05 | 8.68E-05 | 1.E-02 |
All SNP pairs which reached an interaction p-value of P12<1.0×10−4, in addition to PM2<0.05.
*
closest known gene. located >500 kb from associated SNP.
P02– p-value for the test statistic comparing the models M0 (no association) and the general model MG.
P12– p-value for the test test comparing the models MR (heterogeneity) and the general model MG.
PM2– p-value for the test comparing the models MM (multiplicative) and the general model MG.