Table 4. The top heterogeneity results from the 101 two-locus interaction analysis.
| SNP1 | Genes | chr | SNP2 | Genes | chr | N | P02 | P12 | PM2 |
| rs4899272 | ACTN1 | 14 | rs4820682 | SRRD HPS4 TFIP11 ASPHD2 MIR548JTPST2 CRYBB1 CRYBA4 | 22 | 95 | 7.1E-06 | 6.97E-02 | 2.E-02 |
| rs4426448 | DOK6 | 18 | 94 | 9.5E-06 | 6.80E-01 | 1.E-02 | |||
| rs870875 | CD247 | 1 | 94 | 9.4E-05 | 7.19E-02 | 3.E-02 | |||
| rs4842007 | PAEP | 9 | 95 | 8.6E-06 | 5.66E-01 | 4.E-02 | |||
| rs571879 | APPL1 HESX1 IL17RDDNHD2 ASB14 | 3 | rs4385459 | LY96 JPH1 GDAP1 TMEM70 TCEB1 | 8 | 94 | 4.1E-05 | 5.81E-01 | 5.E-02 |
| rs7590305 | FABP1 THNSL2 | 2 | rs390495 | MICAL3 | 22 | 93 | 7.0E-05 | 9.09E-01 | 3.E-03 |
| rs7745052 | FBXL4 C6orf168 USP45COQ3 POU3F2 SFRS18 | 6 | rs4930144 | IGF2AS TH MRPL23 TNNT3 SYT8 ASCL2TNNI2 LSP1 IGF2 INS-IGF2 INS H19 | 11 | 50 | 1.9E-05 | 5.30E-01 | 3.E-02 |
| rs10749738 | FOXD3 | 1 | rs10498982 | EPHA7* | 6 | 93 | 2.0E-05 | 1.95E-01 | 4.E-02 |
| rs2605393 | STAC | 3 | 63 | 7.3E-05 | 4.37E-01 | 4.E-02 | |||
| rs2187668 | HLADQ | 6 | rs11013804 | KIAA1217 | 10 | 94 | 3.5E-14 | 8.40E-02 | 2.E-02 |
| rs1676235 | ESRRB ANGEL1 VASH1 | 14 | 43 | 2.0E-07 | 8.55E-02 | 3.E-02 | |||
| rs958802 | KANK4 L1TD1 INADL | 1 | rs2194633 | NETO1 | 18 | 95 | 1.9E-05 | 5.55E-01 | 3.E-02 |
| rs2345981 | KHDRBS2 | 6 | rs6495130 | RYR3 | 15 | 94 | 6.1E-05 | 1.58E-01 | 3.E-02 |
| rs11940562 | PCDH7* | 4 | rs4905043 | ITPK1 CHGA | 14 | 44 | 4.6E-05 | 2.77E-01 | 2.E-02 |
| rs4656538 | POU2F1 | 1 | rs2187668 | HLADQ | 6 | 94 | 3.0E-13 | 1.19E-01 | 5.E-02 |
| rs3860295 | RASSF5 IKBKE | 1 | rs7046385 | SMC2 | 9 | 94 | 5.3E-05 | 1.07E-01 | 2.E-02 |
| rs6741418 | STAT1 GLS STAT4 | 2 | rs10798004 | C1orf25 C1orf26 IVNS1ABP RNF2 | 1 | 87 | 7.2E-05 | 7.68E-02 | 4.E-02 |
| rs1571812 | VLDLR | 9 | 86 | 3.0E-05 | 9.19E-02 | 4.E-02 | |||
| rs882820 | SRL TFAP4 | 16 | 87 | 4.2E-05 | 3.52E-01 | 6.E-03 | |||
| rs1470379 | VIM | 10 | 82 | 1.0E-05 | 3.70E-01 | 8.E-03 | |||
| rs10946659 | DCDC2 NRSN1 | 6 | 87 | 1.9E-06 | 6.64E-01 | 9.E-03 | |||
| rs10482751 | TGFB2 | 1 | rs1571812 | VLDLR | 9 | 92 | 5.2E-05 | 1.86E-01 | 1.E-02 |
All SNP pairs which reached an interaction p-value of P12>0.05, in addition to PM2<0.05.
*
closest known gene located >500 kb from associated SNP.
P02– p-value for the test statistic comparing the models M0 (no association) and the general model MG.
P12– p-value for the test test comparing the models MR (heterogeneity) and the general model MG.
PM2– p-value for the test comparing the models MM (multiplicative) and the general model MG.