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The two-dimensional free energy profile as a function of Q and the radius of gyration of S6 (a) and Top7 (b) are similar, though Top7 has a wider range of radii of gyration that are low in free energy. The two-dimensional free energy profile as a function of Q and energy of S6 (c) and Top7 (d) are also similar. All free energy profiles were calculated using the “single memory” model with transferable tertiary interactions.
