. 2013 Jan 1;3(1):e23863. doi: 10.4161/biom.23863

Table 1. Application of biopolymers in neural stem/progenitor cell therapy of focal brain ischemic lesion.

Article	Stroke model/ species	Cells transplanted /density per animal	Hydrogel	Outcomes
Bible et al. 2009 Biomaterials⁷²	MCAO/rat	NSC/ 3.15 × 10⁵ cells in 30 µl	Fibronectin-coated PLGA particles	Descriptive analyses of cell survival, cell-scaffold-tissue integration, cell differentiation, angiogenesis and host inflammatory response
Jin et al. 2010 J Cereb Blood Flow Metab.⁷³	MCAO/rat	hES-NPC/ 6 × 10⁶ cells in 50 µl	Matrigel	Reduction in lesion volume, improving cell survival, differentiation and behavioral indices
Yu et al., 2010 Anat Rec (Hoboken)⁷⁴	MCAO/rat	NSC/ 1.5 × 10⁴ in 5 µl	Collagen	Cell survival, NSC synapse formation and neurological severity score improved
Zhong et al. 2010 Neurorehabil Neural Repair¹⁴	PT/mice	ES-NPC / 10⁵ cells in 7 µl	Hyaluronan /Heparin /Collagen	Improving transplant cell survival and host inflammatory response, angiogenesis and astrocytic reactivity
Matsuse et al. 2011 Tissue Eng Part A⁷⁵	MCAO/rat	MS-NSC/ 2 × 10⁴ cells, 12 µl in striatum and 8 µl in cortex	Collagen with bFGF in gelatin microspheres	Infarct volume, cell survival and distribution, angiogenesis, number of host NSCs and motor behavior improved
Bible et al. 2012 Biomaterials⁷⁶	MCAO/rat	hNSC /2.1–2.5 × 10⁶ cells in 25–40 µl	Acellular ECM	Descriptive analyses of cell imaging by MRI, cell migration, differentiation and cell-host tissue interaction

ES, embryonic stem; h, human; MCAO, middle cerebral artery occlusion; MS, mesenchymal stem; NPC, neural precursor cell; NSC, neural stem cell; PLGA, poly(lactic-co-glycolic acid; PT, photothrombotic.