Table 2.

Clinical indices About Severity of Ankylosing Spondylitis

	Freq.a	BASFI	BASDAI	mSASSS	Duration of disease
rs2607142
Levene testb		1.113E-13c	6.052E-12	2.727E-14	1.820E-6
AAd	80	3.635 ± 0.162e	3.775 ± 0.115	9.825 ± 1.520	11.475 ± 0.232
AG	200	3.788 ± 0.102	3.840 ± 0.073	10.890 ± 0.961	11.480 ± 0.147
GG	114	4.553 ± 0.135	4.298 ± 0.096	17.667 ± 1.274	11.526 ± 0.194
Kruskal-Wallis test		0.003*,f	0.038*	0.700	0.948
rs16876619
Levene test		5.187E-9	3.247E-7	8.008E-9	1.041E-7
TT	46	3.717 ± 0.215	3.783 ± 0.153	11.609 ± 2.039	11.457 ± 0.306
CT	170	3.696 ± 0.112	3.824 ± 0.808	10.576 ± 1.061	11.553 ± 0.159
CC	178	4.315 ± 0.109	4.135 ± 0.078	14.865 ± 1.036	11.444 ± 0.155
Kruskal-Wallis test		0.010*	0.215	0.303	0.839
rs4704556
Levene test		4.340E-17	1.462E-11	5.237E-15	0.001
CC	82	4.817 ± 0.158	4.488 ± 0.112	20.683 ± 1.472	11.195 ± 0.232
CT	206	3.794 ± 0.099	3.864 ± 0.071	11.165 ± 0.929	11.597 ± 0.146
TT	106	3.687 ± 0.139	3.717 ± 0.099	9.226 ± 1.295	11.557 ± 0.204
Kruskal-Wallis test		<0.001*	<0.001*	0.014*	0.296
rs16876657
Levene test		0.173	0.299	0.003	0.022
GG	2	3.000 ± 1.054	3.000 ± 0.738	5.000 ± 9.830	12.000 ± 1.453
AG	52	3.923 ± 0.207	3.731 ± 0.145	9.154 ± 1.928	12.192 ± 0.285
AA	340	3.992 ± 0.081	4.000 ± 0.057	13.212 ± 0.754	11.382 ± 0.111
Kruskal-Wallis test		0.371	0.011*	<0.001*	0.138
ANOVA		0.618g	0.097

^aFrequencies of each genotype.

^bLevene test is used to test homogeneity of variance. p-Value less than 0.05 indicates heterogeneity of variance, therefore we use Kruskal-Wallis test, a non-parametric test.

^cp-Value for Levene test.

^dAll clinical indices are analyzed due to the genotype of each SNPs.

^eThe mean ± deviation of each index is calculated for different genotype.

^fp-Value for Kruskal-Wallis test.

^gp-Value for ANOVA.

^*Means significant difference between different genotypes.