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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: Annu Rev Microbiol. 2003;57:609–639. doi: 10.1146/annurev.micro.57.030502.090824

Figure 2.

Figure 2

The ~140-kb KSHV genome composed of a single long unique region with over 80 open reading frames (splice patterns not shown) flanked by G/C-rich terminal repeat units. Gene blocks containing well-conserved herpesviral genes (white) are separated by block of genes unique to KSHV and other rhadinoviruses (black). A full description of the KSHV genes is found in Reference 116. Gene names correspond to positional and sequence homologs found in HVS, which is the prototype rhadinovirus. Genes are numbered from left to right, from ORF4 to ORF75, with the first three homologs to HVS genes being absent or displaced from their corresponding positions in HVS. Genes unique to KSHV, including most of the cell regulatory homologs, are given a K prefix, e.g., ORF K1. Because several HVS genes are absent from the KSHV genome (e.g., ORF1), gene names are not necessarily consecutive.