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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: Annu Rev Microbiol. 2003;57:609–639. doi: 10.1146/annurev.micro.57.030502.090824

TABLE 2.

KSHV genes with antiapoptotic functions

KSHV
protein		 KSHV
gene		 Features and functions Functional
homologs
of other viruses
vFLIP ORF K13 Homolog of cellular apoptosis inhibitor (FLIP);
  transcribed on major latency transcripts (LT)1
  and LT2; posttranscriptional regulation of
  protein expression in vivo		 HVS ORF71
vBCL-2 ORF16 Inhibits bax-mediated apoptosis EBV BHRF-1
vIL-6 ORF K2 B cell proliferation factor; prevents apoptosis in
  IL-6-dependent plasmacytoma cells; binds to
  gp130 subunit of the IL-6 receptor, does not
  require IL6Ra subunit; induces angiogenesis
  and VEGF in rodent fibroblasts; protein
  expressed only in subpopulation of infected
  hematopoietic cells		 EBV gp350/220 and
  LMP1 induces
  cellular IL-6
LANA2 ORF10.5 Inhibits p53-mediated transcription in
  hematopoietic cells		 Mechanism of
  inhibition unknown
vIAP ORF K7 Homolog of survivin-DeltaEx3; glycoprotein
  which can inhibit apoptosis; binds to Bcl2
  via BH2 domain; inhibits caspase-3 activity
  via BIR motif
vIRF-1 ORF K9 Inhibits p53; binds CBP/p300; protein expressed
  in MCD and PEL cell lines		 Adeno E1A, Adeno
  E1A, SV40 LT, EBV
  EBNA2, HTLV Tax