Table 3.
Relationships of common carotid artery intima-media thickness (CIMT) to measures of cortical volume and thickness, reported as B (SE); B=unstandardized regression coefficient, SE=standard error.
| Measure | Region | Intercept B | cIMT B | Age B | Male Gender B | 3T Field strength B | CDR=0 B | ICV B |
|---|---|---|---|---|---|---|---|---|
| Volume (mm3) | Total gray matter | 361903 (38012) | -14216 (20095) | -1488 (435) | -8245 (6947) | 8675 (6421) | 5988 (5545) | 0.100 (0.016) |
| Frontal | 136575 (15246) | -12561 (7885) | -306* (166) | 633 (2779) | 2690 (2604) | 2394 (2238) | 0.040 (0.007) | |
| Parietal | 104097 (11285) | - 10782* (5840) | -305 (121) | 136 (2032) | 492 (1906) | 1935 (1655) | 0.023 (0.005) | |
| Temporal | 111427 (11220) | 1296 (5930) | -672 (127) | -3146 (2027) | 6163 (1893) | 3162* (1613) | 0.029 (0.005) | |
| Occipital | 29937 (4345) | -1578 (2234) | -128 (46) | -307 (786) | 552 (738) | 1178* (628) | 0.007 (0.002) | |
| Average Thickness (mm) | Total gray matter | 2.584 (0.099) | -0.041 (0.059) | -0.003 (0.001) | -0.084 (0.016) | 0.145 (0.016) | 0.039 (0.019) | NA |
| Frontal | 2.345 (0.106) | -0.049 (0.061) | 0.0003 (0.001) | -0.061 (0.017) | 0.149 (0.017) | 0.037 (0.020) | NA | |
| Parietal | 2.534 (0.108) | -0.144 (0.063) | -0.003 (0.001) | -0.075 (0.018) | 0.093 (0.018) | 0.051 (0.021) | NA | |
| Temporal | 3.110 (0.136) | -0.002 (0.082) | -0.008 (0.002) | -0.099 (0.023) | 0.190 (0.022) | 0.067 (0.026) | NA | |
| Occipital | 2.034 (0.117) | -0.077 (0.069) | -0.002 (0.001) | -0.065 (0.019) | 0.050* (0.019) | 0.037* (0.023) | NA |
Bold: adjusted p<0.05;
*
0.05<adjusted p<0.10.
CDR=clinical dementia rating; FCRP=Framingham cardiovascular risk profile; ICV=intracranial volume