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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Inflamm Bowel Dis. 2013 Aug;19(9):1983–1989. doi: 10.1097/MIB.0b013e31829292f7

Figure 2. Specific blockade of VEGFR-3 increases colon inflammation and leukocyte infiltration in the Il10−/− mouse model of IBD.

Figure 2

(A) Representative images of hematoxylin and eosin stained sections of 8-weeks old C3Bir-Il10−/− mice. Scale bars: 100 µm. (B) Histopathological colitis scoring system: evaluation of inflammation severity, epithelial hyperplasia, mucosal ulceration and extent of area involved along the entire colon. (C) The extent of leukocyte infiltration was evaluated along the entire colon length, inspecting the colon mucosa, lamina propria and submucosa areas (t-test *p ≤ 0.05, n=7–8).