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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: Magnes Res. 2011 Sep;24(3):S109–S114. doi: 10.1684/mrh.2011.0286

Figure 1. XMEN patients have a proximal TCR activation defect with loss of Mg2+and Ca2+fluxes.

Figure 1

A) Graph representing the expression of the activation markers CD25, CD95 and CTLA4 in T cells after 3 days of stimulation with 1 ug/ml anti-CD3 (OKT3). The red box represents the normal range. B) Graph representing the nuclear translocation of NF-κB and NFAT after 30 min stimulation with OKT3. C) Mg2+ (upper panel) and Ca2+ (lower panel) fluxes in T cells from normal control or Patient A.1 after 5 ug/ml OKT3 stimulation.