. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Mod Pathol. 2013 Apr 26;26(10):1307–1319. doi: 10.1038/modpathol.2013.74

Table 3.

Distribution of histologic patterns according to mutation.

	Total N=180	Mutation			P value
	Total N=180	EGFR+ n=35	KRAS+ n=63	neg/neg n=82	KRAS+ vs EGFR+	KRAS+ vs neg/neg	EGFR+ vs neg/neg
Lepidic/bronchioloalveolar	35 (19)	15 (43)	7 (11)	13 (16)	<0.001	0.47	0.004
Acinar	106 (59)	28 (80)	34 (54)	44 (54)	0.016	1.00	0.008
Papillary	86 (48)	26 (74)	22 (35)	38 (46)	<0.001	0.18	0.008
Micropapillary	40 (22)	9 (26)	12 (19)	19 (23)	0.45	0.69	0.82
Complex glandular	48 (27)	9 (26)	21 (33)	18 (22)	0.49	0.14	0.64
Solid	51 (28)	2 (6)	28 (44)	21 (26)	<0.001	0.022	0.012
Mucinous	17 (9)	0	7 (11)	10 (12)	0.048	1.00	0.032

The denominator for shown (percentages) is the total number of cases with each mutation. Pattern was defined as “present” using a ≥20% threshold (see Materials and Methods). neg/neg = cases negative for KRAS and EGFR mutations.