Figure 4. Recipient inflammation with poly (I:C) enhances anti-KEL responses, with “boostable” responses.

(A) Serum anti-KEL glycoprotein IgG responses in C57BL/6 animals transfused with KEL2 RBCs in the presence or absence of recipient poly (I:C) pretreatment; straight serum, 14 days post-transfusion. (B) Serum anti-KEL glycoprotein IgG responses after 1, 2, or 3 KEL2 RBC transfusions in the presence of poly (I:C); sera diluted 1:10, tested every 14 days. Results are representative of 2–3 experiments with 3–5 mice/group; *p<0.05