Figure 6. No detectable alloimmune responses to KEL2 RBCs occur in KEL1 recipients (or vice versa), whose KEL RBC antigens differ by a single amino acid polymorphism.
(A) Serum responses of KEL1 or C57BL/6 recipients after 3 transfusions of KEL2 RBCs RBCs. (B) KEL1 RBCs were stained with monoclonal anti-KEL1 (Mima 23) prior to transfusion. Representative serum response of KEL2 (C) or C57BL/6 (D) recipients after 3 transfusions with KEL1 RBCs. Results are representative of 2–3 independent experiments with 2–5 mice/group; *p<0.05.