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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2013 Jun 7;13(4):555–564. doi: 10.1016/j.coph.2013.05.013

Figure 3.

Figure 3

Macrophage reprogramming in vivo. During activation by innate immune stimuli co-ligation of certain macrophage receptors can induce a phenotype conversion of the different types of inflammatory macrophages. Pentraxin 2 reduces fibrosis and promotes resolution by stimulating phenotype switch towards Mreg macrophages. MMP10 inhibits inflammation and tissue damage by stimulating M1 to Mreg macrophage conversion.