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(A) Superimposing 1 and 4 (yellow-blue) onto RNaseA active site (red) in complex with cytidine 3′-monophosphate (green). (B) tRNAPhe tertiary structure (blue backbone following the ribose-phosphate chain) with the cleavage sites (red), magnesium ions (blue), spermine (green-blue). The four main cleavage sites are denoted 1–4. Conjugate 1 cleaves sites 1, 2 and 4, conjugate 2 cleaves sites 1–3, conjugates 4 and 6 cleave sites 1 and 3 and conjugate 5 cleaves only at site 3.
