Fig. 2.

Effect of LTCC activity on EPSPs-2. Pharmacological potentiation of LTCCs augments (short) super-threshold synaptic potentials (“spike events,” a) and promotes the formation of depolarization shifts (see middle traces in a), but at the same time leaves sub-threshold EPSPs (“small events,” b) unaltered. Isradipine reverses the effect of BayK. Each graph shows an overlay of 5 arbitrarily chosen EPSPs recorded in DMSO (dark blue traces), BayK (green traces) and isradipine (red traces). c Overlay of representative traces from this experiment recorded under the three experimental conditions. d Statistical comparisons of small event and spike event data, respectively, from a total of 12 experiments identical to the one illustrated in a–c (see main text for details). n.s. indicates a lack of statistical significance, ***P value <0.001 (Color figure online)