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Skin lesions in patient 1-1. Human papillomavirus-associated pinkish, hypopigmented flat papules on dorsal hands (A) and buttocks (B). C) Histopathology shows hyperkeratosis and acanthosis, with vacuolated cells in the stratum malpighii (arrow), keratinocytes having abundant slightly basophilic cytoplasm (small arrow), and occasional large, round, empty-appearing nuclei (arrowhead). Patients 2-1, 2-2, 3-1, and 3-2 had similar lesions.
