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. 2013 Aug 5;7:136. doi: 10.3389/fnins.2013.00136

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Copyright © 2013 Sia, Whiting, Kyloh, Nicholas, Oliver, Brookes, Dinning, Wattchow and Spencer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graph shows the number of preparations of colon from separate animals that showed a temporary or permanent blockade of peristaltic contractions in control preparations and preparations obtained from animals treated with reserpine prior to being euthanized. (A) Shows control animals, a large proportion of preparations showed a temporary blockade of peristaltic contracions upon application of ondansetron at increasing concentrations of antagonists applied. (B) Similar results were obtained in reserpine-treated preparations with mucosa present. (C) Shows at increasing concentrations of SDZ-205–557 control preparations and reserpine-treated preparations showed a temporary blockade of peristaltic contractions (D). At higher concentrations peristaltic contractions were blocked permanently.