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. 2013 Aug 5;7:136. doi: 10.3389/fnins.2013.00136

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Copyright © 2013 Sia, Whiting, Kyloh, Nicholas, Oliver, Brookes, Dinning, Wattchow and Spencer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of application of SDZ-205-557 or ondansetron on the intervals between repetitive peristaltic contractions. (A) Show a graphical representation of the responses of individual preparations of colon to SDZ-205-557. No clear changes are seen. (B) similar lack of effect of SDZ-205–557 on reserpine treated animals, in which the mucosa was present. (C) Shows the mean changes in interval between peristaltic contractions in control (A) and reserpine-treated (B) preparations overlaid on the same graph. (D) Shows the same experiment as in (A), but ondansetron is used instead of SDZ-205–557. Again, no major changes in intervals were detected. (E) Shows the lack of effect of ondansetron on intervals between peristaltic contractions in reserpine-treated animals, with mucosa present. (F) Shows mean data of (D and E) superimposed. No overall significant effects were detected.