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. 2013 Aug 5;7:136. doi: 10.3389/fnins.2013.00136

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Copyright © 2013 Sia, Whiting, Kyloh, Nicholas, Oliver, Brookes, Dinning, Wattchow and Spencer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In a reserpine-treated animal with mucosa present, combined application of SDZ-205-557 and ondansetron caused temporary inhibition of peristalsitic contractions which recovered even with increasing concentrations up to 5 μM. (B) Shows changes in amplitude of peristaltic contractions from individual animals. It is apparent that when these contractions recovers the amplitudes are unaffected in the majority of preparations, even up to 10 μM in concentration. (C) Shows that 5-HT has been depleted from myenteric ganglia in response to reserpine treatment.