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TLR-4–deficient mice are not protected from saturated fat-induced hepatic steatosis and hepatic insulin resistance. Saturated fat-feeding of TLR-4–deficient mice resulted in hepatic steatosis and an increase in hepatic triglycerides (A), cytosolic- (B), and membrane DAGs (C) as well as ceramides (D). Fatty liver development was associated with membrane translocation of PKCε (E) and insulin resistance as assessed by IPGTT (F). n = 7–10 per group. *P < 0.05.
