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. 2013 Aug 5;3:201. doi: 10.3389/fonc.2013.00201

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Copyright © 2013 Arul and Cho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RSK2 substrates and function of signaling axis. Activated RSK2 by ERK1/2 transfers the phospho-signal to IκBα and caspase-8, results in the regulation of inflammation and apoptosis. On the other hand, activated RSK2 localizes into the nucleus and phosphorylates their substrates such as p53, NFAT3, histone H3, histone 2AX, ATF1, and other substrates. Taken together, these functional signaling pathways regulate diverse biological activities including cell proliferation, transformation, differentiation, survival, and cancer development.