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. Author manuscript; available in PMC: 2014 Aug 12.
Published in final edited form as: Vaccine. 2013 Jun 15;31(36):3675–3682. doi: 10.1016/j.vaccine.2013.06.010

Figure 1. Basophil depletion after vaccination with irradiated L3 larvae does not alter protection against L. sigmodontis challenge.

Figure 1

A) Timeline of experimental protocol. Both vaccinated (Vacc) and vaccinated and basophil-depleted (Vacc+Depl) groups were vaccinated with three weekly subcutaneous injections of 25 irradiated L3s. Both of these groups, plus an unvaccinated control group (No Vacc) were challenged by subcutaneous injection of 40 L3 larvae on day 28 of the protocol, two weeks after the final vaccination. From days 16 (12 days prior to challenge) until study endpoint mice were administered weekly injections of Ba103 to deplete basophils (Vacc+Depl) or isotype control antibody (No Vacc and Vacc groups). B) Number of adult parasites recovered from thoracic cavity at study endpoint four weeks after challenge infection (*** p < 0.001).