Table 1.
Number of eligible BRCA1 mutation carriers by study group
| Study | Countrya | BRCA1 carriers | Genotyping platform |
|---|---|---|---|
| Breast Cancer Family Registry (BCFR) | USA/Australia/Canada | 592 | Taqman |
| Copenhagen Breast Cancer Study (CBCS) | Denmark | 162 | Taqman |
| Spanish National Cancer Centre (CNIO) | Spain | 156 | Taqman |
| CONsorzio Studi ITaliani sui Tumori Ereditari Alla Mammella (CONSIT TEAM) | Italy | 416 | Taqman |
| Deutsches Krebsforschungszentrum (DKFZ) | Germany | 160 | Taqman |
| HEreditary Breast and Ovarian study Netherlands (HEBON) | Netherlands | 773 | iPLEXb |
| Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE) | UK/Eire | 843 | iPLEXb |
| Fox Chase Cancer Centre (FCCC) | USA | 80 | iPLEXb |
| German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC) | Germany | 916 | Taqman |
| Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers (GEMO) | France/USA | 1100 | Taqman |
| Georgetown University (GEORGETOWN) | USA | 33 | iPLEXb |
| Gynecologic Oncology Group (GOG) | USA | 406 | Taqman |
| Hospital Clinico San Carlos (HCSC) | Spain | 116 | Taqman |
| Helsinki Breast Cancer Study (HEBCS) | Finland | 103 | iPLEXb |
| Institut Català d'Oncologia (ICO) | Spain | 113 | Taqman |
| Iceland Landspitali - University Hospital (ILUH) | Iceland | 6 | iPLEXb |
| Interdisciplinary Health Research International Team Breast Cancer Susceptibility (INHERIT BRCAs) | Canada (Quebec) | 73 | Taqman |
| Istituto Oncologico Veneto—Hereditary Breast Ovarian Cancer Study (IOVHBOCS) | Italy | 108 | Taqman |
| Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer (kConFab) | Australia/New Zealand | 526 | iPLEXb |
| Mayo Clinic (MAYO) | USA | 218 | iPLEXb |
| Modifier Study of Quantitative Effects on Disease (MOD SQUAD) | Czech Republic/Belgium | 271 | Taqman |
| General Hospital Vienna (MUV) | Austria | 294 | iPLEXb |
| National Cancer Institute (NCI) | USA | 142 | Taqman |
| Ontario Cancer Genetics Network (OCGN) | Canada | 224 | Taqman |
| Ohio State University Clinical Cancer Center (OSU CCG) | USA | 80 | Taqman |
| Odense University Hospital (OUH) | Denmark | 263 | Taqman |
| Pisa Breast Cancer Study (PBCS) | Italy | 75 | iPLEXb |
| Sheba Medical Centre (SMC)—Tel Hashomer | Israel | 501 | Taqman |
| Swedish Breast Cancer Study (SWE-BRCA) | Sweden | 470 | iPLEXb |
| University of California Irvine (UCI) | USA | 193 | Taqman |
| UK and Gilda Radner Familial Ovarian Cancer Registries (UKGRFOCR) | UK/USA | 187 | Taqman |
| University of Pennsylvania (UPENN) | USA | 274 | iPLEXb |
| Total | 9874 |
aCountry of the clinic at which carriers are recruited.
bCentralized genotyping at Queensland Institute of Medical Research.