Table 2.
Association between rs16942 genotypes on ‘wild-type’ allele of BRCA1 and breast cancer risk
| ‘T’ allele on wild-type (reference) |
‘C’ allele on wild-type |
|||||||
|---|---|---|---|---|---|---|---|---|
| Phasing method (see Materials and Methods) | Unaffected | Affected | Person-years | Unaffected | Affected | Person-years | HR (95% CI)a | P-value |
| rs16942 homozygotes | ||||||||
| Overall | 2065 | 2404 | 185 732 | 607 | 576 | 49 756 | 0.85 (0.74–0.96) | 0.01 |
| Family-based | ||||||||
| Overall | 2339 | 2608 | 206 355 | 1142 | 959 | 87 576 | 0.86 (0.77–0.95) | 0.003 |
| Class 1 mutations | 1636 | 1615 | 205 204 | 904 | 710 | 68 197 | 0.88 (0.79–0.99) | 0.04 |
| Class 2 mutations | 564 | 776 | 68 103 | 166 | 167 | 13 290 | 0.92 (0.71–1.20) | 0.55 |
aHRs and 95% CIs calculated using weighted Cox regressions with a robust sandwich estimator.