| PIKE-S |
PI3K |
Enhancing kinase activity of nuclear PI3K |
| PLCγ1 |
Enhancing PIKE-S GTPase activity |
| 4.1N |
Abolishing PIKE-S/PI3K association |
| BRAG2 |
Accumulating BRAG2 in nucleoli |
| PIKE-L |
PI3K |
Enhancing kinase activity of PI3K |
| Homer 1c |
Activating PI3K by quisqualate |
| Merlin |
Inhibiting merlin-induced PI3K activity |
| UNC5B |
Activating PI3K by netrin-1 |
| SET |
Preventing SET from proteolytic cleavage |
| PIKE-A |
Akt |
Enhancing Akt kinase activity |
| Arf1 |
Enhancing GTPase activity of Arf1 |
| AP1 |
Inhibiting GAP activity of PIKE-A; |
| |
Altering the intracellular localization of AP1 |
| Fyn |
Preventing PIKE-A degradation |
| AMPK |
Regulating AMPK activity |
| CDK5 |
Enhancing the GTPase of PIKE-A |
| FAK |
Enhancing the kinase activity of FAK |
| UNC5B |
Regulating UNC5B apoptosis-inducing effect |
| Insulin receptor |
Inhibiting AMPK phosphorylation |
| STAT5a |
Enhancing STAT5a phosphorylation |
