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. Author manuscript; available in PMC: 2013 Aug 5.
Published in final edited form as: Psychopharmacology (Berl). 2007 Jun 9;194(1):117–125. doi: 10.1007/s00213-007-0827-7

Figure 2. Relapse to cocaine seeking induced by exposure to non-contingent cocaine cues: between-subjects analysis.

Figure 2

(A) Mean±sem number of lever presses on the previously active lever and on the inactive lever in two groups of rats that were either exposed (n=12) or not exposed (n=12) to non-contingent cue presentations during a single test session after 3 d of self-imposed abstinence induced by exposure to the electric barrier. (B) Mean number of active and inactive lever responses of individual rats in the non-contingent cue condition. In the non-contingent cue session, the rats were exposed to the light cue previously paired with cocaine injections during the 30-min sessions every 5 min for 20 sec. During testing, the rats had to cross the electric barrier in order to gain access to the levers. Lever responding during testing was conducted under extinction conditions and resulted in contingent presentation of the discrete light cue under a fixed-ratio-2 20 sec timeout reinforcement schedule, but not cocaine. * Different from the no non-contingent cue control condition, p<0.05; # Different from the inactive lever, p<0.05.