Fig. 6. Switch-over to a gfd leads to reversal of weight loss and improvement of enteropathy.
a) Changes in body weight of Rag1−/− mice during 21.5 weeks after transfer of gliadin-presensitized CD4+CD45RBlowCD25− T cells. Immediately after introduction of a gfd at week 10.5 (↑), the diet switch-over group is gaining weight compared to the gliadin/gluten group (***p<0.001). Significantly lower weights in the gliadin/gluten and the diet-switch-over vs. the gliadin/gfd group (+++p<0.001, °°°p<0.001, n=8–9). b) Exacerbation of histological duodenitis in the gliadin/gluten vs. the gliadin/gfd group at 21.5 weeks (*p<0.05), but non-significant difference for the diet switch-over vs. the gliadin/gfd group (p=0.11, n=8–9). c) Decreased duodenal transcript levels for IFNγ and IL-17A (both *p<0.05), and non-significant decreases for IL-17F (p=0.13) and IL-2 (p=0.15) in the diet switch-over vs. gliadin/gluten group (n=8).