Skip to main content
. Author manuscript; available in PMC: 2014 Jun 21.
Published in final edited form as: Soft Matter. 2013 May 7;9(23):5516–5523. doi: 10.1039/C3SM50798J

Fig. 4. LINC-mediated formation of the actin cap in cellular mechanotransduction.

Fig. 4

Schematic of an adherent cell exposed to fluid flow shear force. Left, micrograph shows a serum-starved control C2C12 mouse myoblast cell (which contains no organized actin structures before stimulation) that forms an organized actin cap (inset) in response to exposure of a shear stress of 5 dyn/cm2 for 5 min. The right micrograph shows a serum-starved C2C12 cell that has been shRNA-depleted of LINC complex protein nesprin3. This cell is unable to form an organized actin cap after exposure to the same fluid shear stress.