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. Author manuscript; available in PMC: 2013 Aug 5.

Published in final edited form as: Adv Exp Med Biol. 2010;687:49–63. doi: 10.1007/978-1-4419-6706-0_3

Table 1.

BH3-only proteins implicated in apoptosis due to various treatments

Cancer Treatment	Cellular Damage	BH3-Only Proteins
5-Fluorouracil	DNA synthesis inhibitor	Bim,⁹⁶ Puma,⁹⁶ Bad⁹⁷ and Bid^57,98
Adriamycin	DNA damaging agent	Bim,⁹⁹ Bik,⁷⁰ Bid¹⁰⁰ and Puma²³
Bortezomib	Proteasome inhibitor	Bim,¹⁰¹ Noxa¹⁰¹ and Bik¹⁰¹
Etoposide	DNA damaging agent	Bim,⁹⁹ Bid,^102,103 Puma⁷³ and Noxa⁷³
Gefitnib	EGFR inhibitor	Bim¹⁰⁴ and Bad¹⁰⁵
Glucocorticoid	Antagonize immune cells	Bim^106–108 and Puma¹⁰⁷
HDAC inhibitor	Inhibit histone deacytylse	Bim¹⁰⁹ Bmf¹¹⁰
Imatinib	Kinase inhibitor	Bim,¹¹¹ Bmf¹¹¹ and Bad¹¹¹
Irradiation	DNA damaging agent	Bim,¹⁰⁷ Bid¹¹² and Puma^73,107
MEK inhibitors	MAPK inhibitor	Bim¹¹³ and Bmf¹¹³
Paclitaxel	Microtubule inhibitor	Bim^114–116