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Potential anti-virulence strategies with small molecule inhibitors of type III secretion systems (T3SSs) in Gram-negative bacterial pathogens. A. T3SS effectors that kill the host cells (for example, in Pseudomonas aeruginosa with translocation of ExoU). B. T3SS allow entry and replication in the host cells (for example, in Salmonella invasion and replication in the Salmonella-containing vacuole (SCV)). Legends are indicated in the bottom grey box.
