Table 1.
Compound | Regulation | Secretion/Translocation | T3SS IC50 | Infection | Other Pathways | Ref |
---|---|---|---|---|---|---|
1 INP-0007, D8 |
C trachomatis: Down-regulates transcription of late-cycle virulence genes |
C. trachomatis: Prevents IncA secretion during infection S. typhimurium Y. pseudo-tuberculosis Y. pseudo-tuberculosis: Prevents YopH translocation into HeLa |
~15 μM ~5 μM* |
C. trachomatis: Inhibits replication in HeLa S. typhimurium: Reduces hemolysis of erythrocytes, invasion of HeLa, and immune response in bovine ligatcd loop model Y. pseudo-tuberculosis: Inhibits invasion of HeLa |
Y. pseudo-tuberculosis: Inhibits motility | 21, 26, 31, 35, 38 |
2 1NP-0010, D9, ME0052 |
C. pneumoniae, S. typhimurium: Down-regulates transcription of some virulence genes EHEC: Down-regulates transcription of LEE but not iron-related genes |
EHEC: Inhibits Tir and EspD secretion S. typhimurium |
~25 μM |
C trachomatis: Inhibits replication in mammalian cell lines S. typhimurium: Inhibits invasion of MDCK cells and replication in macrophages Y. pseudo-tuberculosis: Reduces macrophage cytotoxicity |
27, 32, 26 | |
3 INP-0031, ME0055 |
EHEC: Down-regulates transcription of LEE but not iron-related genes and up-regulates flagellum expression | EHEC: Inhibits Tir and EspD secretion | ~25 μM | EHEC: Reduces number of A/E lesions on bovine epithelial cells | 27 | |
4 INP-0400, D1 |
S. flexneri: Affects needle complex assembly |
S. typhimurium S. flexneri |
C. trachomatis: Inhibits replication in HeLa and McCoy cells S. typhimurium: Reduces HeLa cytotoxicity S. flexneri: Reduces invasion of HeLa and macrophage cytotoxicity |
33, 34, 36, 39 | ||
5 INP-0403, D4 |
S. typhimurium: Down-regulates transcription of invC and hilD but not hilA or effectors | S. typhimurium | ~25 μM | S. typhimurium: Reduces hemolysis of erythrocytes, invasion of HeLa, and immune response in bovine ligatcd loop model | S. typhimurium: Effects reversed with exogenous iron | 35, 36, 37 |
IC50 value was determined by fluorescence detection from the carboxypeptidase G2-SopE2 reporter construct in S. typhimurium38.