Table 2.
Compound | Regulation | Secretion/Translocation | T3SS IC50 | Infection | Other Pathways | Ref |
---|---|---|---|---|---|---|
1 TTS29 |
S. typhimurium: Inhibits needle complex assembly, No effect on general transcription |
S. typhimurium Y. enterocolitica F. tularensis |
83 μM |
P. syringae: Prevents HR response in tobacco leaves S. typhimurium: Reduces macrophage cytotoxicity |
S. typhimurium: No effect on flagellar system or motility P. aeruginosa: Inhibits T4-dependent motility & T2S |
41, 42, 43 |
2 TTS29-analog |
S. typhimurium: No effect on general transcription | S. typhimurium: | 3 μM | S. typhimurium: Reduces macrophage cytotoxicity | P. aeruginosa: Inhibits T2S | 41, 42, 43 |
3 |
S. typhimurium: Inhibits secretion of SipA | 5 μM | 43 |