Table 3.
Representative compounds | Regulation | Secretion/Translocation | T3SS IC50 | Infection | Other Pathways | Ref |
---|---|---|---|---|---|---|
1 |
S. typhimurium (SipA, SopE) P. aeruginosa (ExoU) |
44 | ||||
2 |
exoT transcription |
Y. pestis (YopE-βla) P. aeruginosa (ExoS) |
12.5 μM for ExoS 22 μM for YopE |
Inhibits P. aeruginosa ExoU-dependent CHO cytotoxicity Inhibits C. trachomatis growth in Hep-2 cells |
No effect on type II-mediated elastase secretion | 45 |
3 |
No effect on needle assembly |
Y. pseudo-tuberculosis YopE-βla translocation P. aeruginosa |
Reduces Hcp-2 ccll-rounding by P. aeruginosa | Increases Yop leakage C20 reduces adherence of Hcp-2 cells |
46 | |
4 |
yopE transcription No effect on OmpA level in EPEC |
Y pestis (effectors) YopE-βla translocation EPEC (Tir) |
10–15 μM for Yops | Reduces HcLa cells toxicity by Y. pestis | 47 | |
5 |
S. typhimurium (SipB) P. aeruginosa (ExoU) |
20–80 μM for SipB >100 μM for ExoU |
48 | |||
6 Pseudolipasin A |
No effect on P. aeruginosa secretion | Protects CHO cells cytotoxicity from the P. aeruginosa effector ExoU Prevents P. aeruginosa-rnediated killing.of Dictyostelium discoideum Inhibits ExoU-mediated killing of Saccharomyces cerevisiae |
49 | |||
7 |
Y. pseudotuberculosis | Y. pseudotuberculosis cytotoxicity | 50 | |||
8 |
Y. pestis (YopE) | 20 μM | Protects Y. pestis cytotoxicity | ATPase activity of BsaS protein from Burkholderia mallei | 51 | |
9 Caminoside A |
No effect on typc-V effector EspC | EPEC (EspB) | 20 μM | 52, 53 | ||
10 Guadinomines |
EPEC | 20 nM in hemolysis assay | Prevents hemolysis of erythrocytes | 54, 55, 56 | ||
11 Aurodox |
No effect on expression of GroEL | EPEC (EspA, EspB, EspD) | 1.5 μg/ml in hemolysis assay | Prevents hemolysis of erythrocytes Protects Citrobactor rodentium infection |
57 |