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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Front Biosci (Schol Ed). 2013 Jan 1;5:261–276. doi: 10.2741/s371

Figure 8. Decreased dopamine release and uptake following cocaine self-administration.

Figure 8

Shown are representative concentration-time plots of dopamine responses in the presence of 10 microM cocaine applied to a brain slice containing the NAc core. Dopamine release is greater and uptake is faster in naïve rats (left) relative to rats which have self-administered cocaine (right). Further, the effects of cocaine are greatly reduced in animals with a history of cocaine self-administration.